---
title: "App Note: Efficient screening of copolymer nanodiscs to optimize membrane proteins for cryo-EM"
description: App Note - Efficient screening of copolymer nanodiscs to optimize membrane proteins for cryo-EM
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---

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# App Note

# Efficient screening of copolymer nanodiscs to optimize membrane proteins for cryo-EM

 

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With the use of innovative solubilization approaches, such as synthetic copolymers, structural biologists can efficiently create soluble membrane proteins optimized for cryo-EM workflows.

In this application note, learn how to screen for the optimal copolymers using a combination of parameters from the Prometheus Panta instrument for stability characterization of membrane proteins.

You'll learn:

- How to rapidly screen a series of several copolymers nanodiscs using the NativeMPTM platform
- How to use parameters from isothermal DLS measurements on Prometheus Panta to select the best copolymers
- Which additional stability information can be derived from nanoDSF data, acquired using the same sample

 

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