---
title: App Note - What dose–response and orthogonal assays revealed about MEK1 screening
description: App Note - What dose–response and orthogonal assays revealed about MEK1 screening
image: https://info.edifydigitalmedia.com/hubfs/Nanotemper%20Featured%20Image%20HS%20-%2027.04.26.png
---

[Skip to content](https://info.edifydigitalmedia.com/app-note-what-dose-response-and-orthogonal-assays-revealed-about-mek1-screening#main-content)

[![DDW Hi Res Logo](https://info.edifydigitalmedia.com/hs-fs/hubfs/DDW%20Hi%20Res%20Logo.jpg?width=250&height=118&name=DDW%20Hi%20Res%20Logo.jpg "DDW Hi Res Logo")](https://www.edifydigitalmedia.com/)

![Nanotemper CMP Landing Page Banner - 27.04.26-1](https://info.edifydigitalmedia.com/hs-fs/hubfs/CMP%20images/Nanotemper%20CMP%202-2%20App%20Note%20-%2027.04.26/Nanotemper%20CMP%20Landing%20Page%20Banner%20-%2027.04.26-1.png?width=1425&height=400&name=Nanotemper%20CMP%20Landing%20Page%20Banner%20-%2027.04.26-1.png "Nanotemper CMP Landing Page Banner - 27.04.26-1")

 

This study highlights the Dianthus™ uHTS platform for biophysical screening of MEK1, a key kinase in the MAPK/ERK pathway. Using Spectral Shift technology, ~5,120 compounds were profiled in single-dose mode, generating ~250,000 data points per day.

![Nanotemper CMP Asset Image - 27.04.26](https://info.edifydigitalmedia.com/hs-fs/hubfs/CMP%20images/Nanotemper%20CMP%202-2%20App%20Note%20-%2027.04.26/Nanotemper%20CMP%20Asset%20Image%20-%2027.04.26.jpg?width=208&height=270&name=Nanotemper%20CMP%20Asset%20Image%20-%2027.04.26.jpg)

Download the application note to learn more about:

- Ultra-high-throughput biophysical screening enabled by Spectral Shift technology

- Rapid identification of high-affinity hits from large compound libraries
- A low sample consumption biophysical method with broad applicability across diverse target classes

 

     Sponsored by 

![NanoTemper-logo](https://info.edifydigitalmedia.com/hs-fs/hubfs/CMP%20images/Nanotemper%20CMP%20(Lea)%20-%2023.04.26/NanoTemper-logo.jpg?width=272&height=49&name=NanoTemper-logo.jpg)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Copyright 2026 Drug Discovery World. All Rights Reserved  
[Privacy Policy & Cookies](https://www.ddw-online.com/privacy-policy/) | [Contact](https://info.edifydigitalmedia.com/hubfs/In%20Focus%20eReport_Mar26_Antibody-based%20drugs.pdf?hsLang=en) | [Terms & Conditions](https://www.ddw-online.com/terms-and-conditions/)