As the demand for mRNA-based therapies surges, the efficiency of the production process becomes paramount. Binding conditions in affinity chromatography need to be optimised, to keep up with the increasing efficiency of IVT reactions, and to deliver high yields and purities.

In this application note, we demonstrate that multi-parallel approaches, such as screening in 96-well plate format, can significantly cut the development time by enabling the examination of multiple conditions simultaneously.

In this application note, we show:

• Innovative strategies for maximising the dynamic binding capacity of Oligo dT
• How multi-parallel approaches significantly cut the development time by testing numerous conditions in parallel
• Insightful analysis of the critical factors influencing binding efficiency
• Guidance on transitioning/scalability to larger chromatographic columns for industrial applications
  

  Download now to access the application note and elevate your drug development strategies to new heights.

Brought to you by Sartorius BIA Separations