Among the most common critical quality attributes (CQAs) for early developability assessment is thermal stability. One particular tool for assessing thermal stability with high resolution is nano-differential scanning fluorimetry (nanoDSF).
Read this mini-guide to learn:
- How nanoDSF uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton
- Why high-resolution unfolding data is critical for obtaining stability information about your mAbs
- What some real-life examples of nanoDSF data look like, and what to look for in your own samples
Brought to you by
