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The development of therapeutic treatments is a challenging process linked to understanding mechanisms that underly human disorders. Finding the relevant biological model has been a limiting process so far. The development of induced pluripotent stem cell (iPSC) technology has revolutionized the way we study complex disorders. iPSCs offer a unique in vitro platform for generating large quantities of cells for disease modeling, drug screening, and ultimately cell-based therapy. By combining such a platform with CRISPR-Cas9 gene editing technology, Horizon unlocks the potential to produce engineered iPSCs for a wide range of tissues and diseases.

Leveraging more than a decade of cell line engineering experience and with its optimal workflows, Horizon is able to deploy a highly efficient and highly scalable iPSC gene-editing platform to offer a wide range of cell line engineering services ranging from:

  • Gene knockout
  • Single nucleotide polymorphism (SNP) or point mutations
  • Fluorescent reporter cell lines
  • Inducible gene expression

Here, we demonstrate Horizon’s efficient gene editing platform and capabilities to edit complex pluripotent stem cells for disease modeling.


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