Working in PROTACs, you’re tasked with the most challenging targets — that aim to address intractable diseases such as cancer, Alzheimer's, or Parkinson's disease. Despite the impressive promise of PROTACs, you still have to overcome many hurdles in order to work with these difficult targets.
This guide highlights the four major stages of targeted protein degradation, the challenges at each step, and questions you should ask yourself to make sure your final product will result in a complete protein degradation.
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