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Antibody Internalization: Advanced screening method provides greater speed & insight

Researchers abilities to improve the breadth of therapeutic antibodies have been aided by innovative technologies for antibody discovery, for instance, through humanization of mouse antibodies and phage display. However, advanced antibody design techniques create the need for new screening methods so that lead candidates can be quickly and effectively identified early in development.

A solution to address these challenges is to use advanced screening methods that offer maximum insight through high-content data. Herein, we demonstrate an advanced antibody screening method that focuses on speed and insight by using a novel, pH-sensitive reagent for characterizing antibody internalization via both advanced flow cytometry and live-cell imaging.