Cancer is a complex disease that continuously evolves in response to environmental pressures. The dynamism and heterogeneity of tumours have significant clinical implications. In this eBook, we review how single-cell DNA sequencing and multi-omics are used to dissect clonal architecture, providing valuable insights for clinical strategies, disease modelling, and the development of cell and gene therapies.

Specifically, we cover:

• The clonal evolution of cancer
• Linking genotype & phenotype with multi-omics
• Translational applications for the clinic
• Single-cell analysis of genome engineering